It is not clear if this alpha chain variant affects the TSLP receptor.īecause the IL7R gene is involved in regulation of the immune system, changes in it might be involved in the autoimmune response and inflammation that damage nerves and the protective coating surrounding them (the myelin sheath), leading to the signs and symptoms of multiple sclerosis. The IL-7 receptor that contains this version of the alpha chain is not embedded in the cell surface but is instead found inside the cell. The genetic variation involved in multiple sclerosis affects a single protein building block (amino acid) in the IL-7 receptor alpha chain, specifying the amino acid isoleucine at position 244 instead of the amino acid threonine (written as Thr244Ile). This condition affects the brain and spinal cord (central nervous system), causing muscle weakness, poor coordination, numbness, and a variety of other health problems. Attachment of TSLP to its receptor triggers a set of signals that support proliferation and maturation of a variety of immune system cells.Ī common variation of the IL-7R gene increases the risk of developing multiple sclerosis. Similarly, the TSLP receptor interacts with the cytokine TSLP. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells. In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. The receptor and cytokine fit together like a lock and its key, triggering a series of chemical signals inside the cell. IL-7 is a cytokine, which is a protein that regulates the activity of immune system cells. These cells identify foreign substances and defend the body against infection and disease.Īt the cell surface, the IL-7 receptor interacts with a protein called IL-7. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. ![]() These receptors are embedded in the cell membrane of immune system cells. ![]() This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |